An Optimization Method for a Successive Fed-batch Operation
نویسندگان
چکیده
منابع مشابه
Optimization of A Fed-Batch Fermenter Producing Bakerâs Yeast Using Simulated Annealing Method
Modeling of fermentation processes is so complicated and uncertain; therefore it is necessary to provide a robust and appropriate dynamic optimization method. In order to obtain the maximum amount of yeast (Saccharomyces cerevisiae), the bioreactor must be operated under optimal conditions. To determine substrate feeding in a fed-batch bioreactor, a simulated annealing (SA) approach was examine...
متن کاملoptimization of a fed-batch fermenter producing bakerâs yeast using simulated annealing method
modeling of fermentation processes is so complicated and uncertain; therefore it is necessary to provide a robust and appropriate dynamic optimization method. in order to obtain the maximum amount of yeast (saccharomyces cerevisiae), the bioreactor must be operated under optimal conditions. to determine substrate feeding in a fed-batch bioreactor, a simulated annealing (sa) approach was examine...
متن کاملEvolutionary Strategy for Feeding Trajectory Optimization of Fed-batch Reactors
Safe and optimal operation of complex production processes is one of the most important research and development problems in process engineering. This problem is the most relevant at the design of the optimal feeding profile of fed-batch chemical reactors due to the nonlinear and unstable dynamical behavior of the processes. This paper shows that how the optimal feeding policy can be determined...
متن کاملFed-Batch Cell Culture Process Optimization A Rationally Integrated Approach
level: intermediAte Most biopharmaceutical production platforms are based on fed-batch cell culture protocols, which can support high volumetric productivity while maintaining low operational complexity (1). The industry is interested in developing or refining high-titer cell culture processes to meet increasing market demands and reduce manufacturing costs (2). Although advancements in cell en...
متن کاملOptimization of a Fed-batch Bioreactor Using Simulation-based Approach
We use simulation-based approach to find the optimal feeding strategy for cloned invertase expression in Saccharomyces cerevisiae in a fed-batch bioreactor. The optimal strategy maximizes the productivity and minimizes the fermentation time. This procedure is motivated from Neuro Dynamic Programming (NDP) literature, wherein the optimal solution is parameterized in the form of a cost-to-go or p...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: KAGAKU KOGAKU RONBUNSHU
سال: 1984
ISSN: 0386-216X,1349-9203
DOI: 10.1252/kakoronbunshu.10.489